Don't miss

Replay


LATEST SHOWS

DEBATE

François of Arabia: Hollande's Budding Friendship with the Gulf (part 2)

Read more

DEBATE

François of Arabia: Hollande's Budding Friendship with the Gulf (part 1)

Read more

TALKING EUROPE

Guy Verhofstadt: Lack of EU asylum system is 'pushing people to come to Europe'

Read more

FOCUS

The health risk behind Argentina's soya paradise

Read more

TALKING EUROPE

Disability discrimination: Removing the obstacles to success

Read more

ENCORE!

Music show: Mumford & Sons and the 'Queen of British Blues'

Read more

FASHION

30th International Festival of Fashion and Photography in Hyères

Read more

THE WORLD THIS WEEK

The Right to Offend: Writers to Boycott Charlie Hebdo PEN Award

Read more

DOWN TO EARTH

Ethiopia's green renaissance

Read more

Liver transplant changed Australian girl's blood group

Latest update : 2008-01-24

A 15-year-old Australian girl had her blood group and immune system switched to her donor's after she received his liver. This is an unprecedent case in medical history.

An Australian girl spontaneously switched blood groups and adopted her donor's immune system following a liver transplant in the first known case of its type, doctors treating her said Thursday.

Demi-Lee Brennan was aged nine and seriously ill with liver failure when she received the transplant, doctors at a top Sydney children's hospital told AFP.

Nine months later it was discovered that she had changed blood types and her immune system had switched over to that of the donor after stem cells from the new liver migrated to her bone marrow.

She is now a healthy 15-year-old, Michael Stormon, a hepatologist treating her, told AFP. Stormon said he had given several presentations on the case around the world and had heard of none like it.

"It is extremely unusual -- in fact we don't know of any other instance in which this happened," Stormon told AFP from the Children's Hospital.

"In effect she had had a bone marrow transplant. The majority of her immune system had also switched over to that of the donor."

An article on the case was published in Thursday's edition of the leading US medical journal The New England Journal of Medicine.

Doctors who treated Brennan say she is now only under treatment as an outpatient and are interested to know if the case could have other applications in transplant surgery, where rejection of donor organs by the recipient's immune system is a major hurdle.

Stormon said it appeared that Brennan may have been fortunate because a "sequence of serendipitous events", including a post-transplantation infection, may have given the stem cells from her donor's liver the chance to proliferate.

The task now was to establish whether the same sort of outcome could be replicated in other transplant patients, he said.

Date created : 2008-01-24

COMMENT(S)