Hollywood megastars Brad Pitt and George Clooney kick off this year's Venice film festival on Wednesday with the world premiere of the latest quirky offering from the Oscar-winning Coen brothers.
  
The festival, running through September 6, is set to bring a bevy of stars to one of the world's top cinema showcases, including Charlize Theron of South Africa and US star Kim Basinger, as well as new offerings by top filmmakers such as Takeshi Kitano and Jonathan Demme.
  
Kicking off the celebrations but shown out of competition, the Pitt-Clooney crime comedy "Burn After Reading" by 2008 Oscar-winning duo Joel and Ethan Coen also stars John Malkovich and Tilda Swinton.
  
In the film, the star pair play two middle-aged gym employees who stumble on the memoirs of a retired CIA agent and try to sell the manuscript to finance cosmetic surgery.
  
Oscar winners Theron and Basinger play in "The Burning Plain", Mexican-born screenwriter Guillermo Arriaga's first shot at directing.
  
Of the 52 films selected to screen at this year's Venice Mostra, 21 will be competing for the Golden Lion top prize, including the latest films of Japanese directors Kitano and Hayao Miyazaki.
  
Both Kitano's "Achilles and the Tortoise" and Miyazaki's animated feature "Ponyo on the Cliff by the Sea" are tipped as favourites for the top prize.
  
Other strong runners include US director Darren Aronofsky's "The Wrestler", starring Mickey Rourke, and French filmmaker Barbet Schroeder's thriller set in Japan, "L'Inju: La Bete dans l'Ombre" (The Beast in the Shadow).
  
Meanwhile "Silence of the Lambs" director Demme will present the much anticipated comedy "Rachel Getting Married", starring Anne Hathaway as a troubled young woman showing up at her estranged sister's wedding.
  
An African film in the running is "Teza" by US-based Ethiopian veteran Haile Gerima tracing the life of a young Ethiopian from his student days in West Germany in the 1970s to his return to his native village at the age of 60.
  
From north Africa is Franco-Algerian cineaste Tariq Teguia's "Gabba" (Inland).
  
Veteran German director Wim Wenders, the man behind "Buena Vista Social Club" and "Paris, Texas", will head this year's jury, which includes Italian actress Valeria Golino, Argentine filmmaker Lucrecia Martel and Hong Kong's Johnnie To.
  
Festival director Marco Mueller said this year's festival would be dedicated to Egyptian filmmaker Youssef Chahine, who died on July 27 aged 82.
  
A career Golden Lion has been reserved for Italian director Ermanno Olmi, 77, whose 1978 neo-realist epic "L'Albero degli Zoccoli" (The Tree of Wooden Clogs) won the Golden Palm at Cannes and many other awards.