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Japanese scientist who led controversial stem cell research found hanged

Toru Yamanaka, AFP | Yoshiki Sasai at a press conference in April 2014.

A Japanese scientist at the center of research initially hailed as a breakthrough for stem cell treatment killed himself after months of stress and exhaustion, officials said on Tuesday.


Yoshiki Sasai was the co-author of the high-profile study that had seemed to offer hope for replacing damaged cells or even growing new human organs.

He was found dead early on Tuesday at the Riken institute where he worked in Kobe, Japan, police and the institute said.

"It is confirmed as a suicide," said a police spokesman. "It was a hanging."

Sasai, 52, had been hospitalized in March for stress and become less receptive to media inquiries during the controversy over the team's research, Riken spokesman Satoru Kagaya said.

The scientist "had seemed completely exhausted" in their last phone conversation around May or June, Kagaya told a televised news conference.

As deputy director of Riken's Center for Developmental Biology, Sasai supervised the work of lead author Haruko Obokata, which took the world of molecular biology by storm when it was published in the British journal Nature in January.

It was retracted after months of controversy that made front-page news in Japan and tarnished the country's reputation for scientific research.

The journal's editor-in-chief, Phil Campbell, issued a statement in London describing Sasai's death as a true tragedy for science and an immense loss to the research community.

"Yoshiki Sasai was an exceptional scientist and he has left an extraordinary legacy of pioneering work across many fields within stem cell and developmental biology," Campbell said.

Japan's top government spokesman, Chief Cabinet Secretary Yoshihide Suga, said the suicide was "very unfortunate.”

"Mr Sasai contributed greatly in the field of developmental biology and was an internationally renowned researcher."

Riken president Ryoji Noyori expressed "deep regret over the loss of an irreplaceable scientist."

In what looked like game-changing discovery, Obokata, Sasai and the other authors described simple ways to reprogramme mature animal cells back to an embryonic-like state, allowing them to generate many different types of cells.

But questions soon arose about the research, as other scientists could not replicate the startling claims. Riken said its investigation found Obokata had plagiarized and fabricated parts of the papers, raising doubts about the credibility of Japanese science.

After defending her work for months against Riken's claims, Obokata agreed in June to retract the papers, which Nature did in early July.

Despite the retractions of the research papers, Sasai never wavered in his belief that Stimulus-Triggered Acquisition of Pluripotency, or STAP, cells could exist, Japanese media said.

Obokata was "very shocked" at Sasai's suicide and was being assisted by two Riken staffers, Kagaya said.

Sasai left five suicide notes, including two addressed to senior Riken officials, he said. He would not disclose the contents or to whom the other letters were addressed.

Sasai started receiving counselling in April and recently had trouble communicating due to side-effects of medical treatments he was undergoing, local media reported.


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